B2266 - The role of metabolomics and gut microbiome in modifying arterial disease progression in relation to adiposity - 10/07/2014

B number: 
B2266
Principal applicant name: 
Prof John Deanfield (University College London, UK)
Co-applicants: 
Prof Nicholas Finer (University College London, UK), Prof Nishi Chaturvedi (Imperial College London, UK), Prof Alun Hughes (Imperial College London, UK)
Title of project: 
The role of metabolomics and gut microbiome in modifying arterial disease progression in relation to adiposity.
Proposal summary: 

AIMS

1. To assess whether change in dietary habits from adolescence to young adulthood can modify the gut flora, increase the production of noxious metabolites (TMAO) and accelerate arterial disease progression.

2. To assess whether dietary supplementation of probiotics can modify the gut flora and can benefit the lipid profile and vascular risk of overweight and obese individuals

Date proposal received: 
Monday, 30 June, 2014
Date proposal approved: 
Thursday, 10 July, 2014
Keywords: 
Diet, Metabolomics, Microbiome
Primary keyword: 
Cardiovascular