The primary intent of ROHgen is to investigate the influence of ROH on complex traits; to show for which traits and end points there is evidence of recessive effects, how strong they are and eventually potentially to count and map these effects. This will be done by conducting the same analyses across many cohorts and then sharing various statistics relating to ROH or trait associations for central meta-analysis.

Hypothesis: ROHs are associated with health-related outcomes and quantitative traits of interest.