Objective 1: To generate and supplement existing genetic, epigenomic and metabolomic data across five large European cohort studies to provide an unparalleled resource for investigating associations between early life factors and subsequent obesity, neurodevelopmental and mental health outcomes.

Objective 2: To integrate inter-generational phenotypic, genetic, epigenomic and metabolomic data across the five cohort studies through harmonization of data and meta-analysis.

Objective 3: To identify causal relationships between prenatal exposures and metabolic and neurodevelopmental outcomes using a variety of state-of-the-art causal analytic methods including Mendelian randomization, maternal-paternal, between-sibling and cross-cohort comparisons.

Objective 4: To synthesise information to inform and prioritise future interventions and public health policy that will have a meaningful and lasting impact upon the incidence of these health challenges.