B2309 - Genomewide association study for BMI in infants and children the Early Growth Genetics consortium - 23/10/2014
B number:
B2309
Principal applicant name:
Janine Felix (Erasmus University Medical Center, Rottterdam, the Netherlands, Europe)
Co-applicants:
Dr Evie Stergiakouli (Univeristy of Bristol, UK), Nick Timpson (Univeristy of Bristol, UK)
Title of project:
Genomewide association study for BMI in infants and children: the Early Growth Genetics consortium
Proposal summary:
The analyses to be undertaken for this project at simple and require only a number of basic procedures. These will all be run by local ALSPAC analysts (Timpson or Stergiakouli) and only results provided for the work of the consortium. Analyses follow:
(i) GWAS for BMI (see attached protocol (based on the 1000g analysis, though this is the same for the HAPMAP imputation based analyses) for this procedure)
(ii) Sensitivity analyses (slight alterations to models run for GWAS, but no substantive changes)
(iii) For top SNP variants, expression data available on ALSPAC LCLs will be assessed in efforts to chart cis eQTLs relevant to implicated genetic signals.
Date proposal received:
Wednesday, 15 October, 2014
Date proposal approved:
Thursday, 23 October, 2014
Keywords:
GWAS
Primary keyword:
BMI