Analysis of the ALSPAC data forms part of a larger grant application examining the genetic markers of phenotypic measures of emotional reactivity in early childcare settings. More specifically, the ALSPAC data will be used for the validation of a GWAS study examining associations with individual temprements and will form a cross-test of methodological reliability.

AIMS. The aims of the broader research program are to:

1.Characterise individual difference in child emotional reactivity through assessment of the the statistical association of genotype with physiological, observational, physiological, and report measures.

2.Examine the interaction of child emotional reactivity with qualities of the childcare environment to and assess impact on social-emotional regulation and behavioural development.

3.Identify the meaning of individual difference in children's reactivity for policy and practice in childcare settings.

The specific aims relevent to the use of the ALSPAC data will be to valiate genotypic markers identified within our target cohort, by examining the same geneotypes and their association with phenotypic variables of temprement, sleep, behaviour and behavioural diagnoses within the ALSPAC data set.

VARIABLES

Genotypes of interest will be ientified via an indepenent cohort study to be conducte as part of the grant application and are not known at this time. Phenotypic variables of interest will be temperament, behaviour, behavioural diagnoses and sleep characterisitcs. Socio-economic status and childcare charatersitics of the children are also requested.