B2346 - Understanding variability in cardio-metabolic risk in the ALSPAC cohort - 27/11/2014
B number:
B2346
Principal applicant name:
Dr Jonathan Wells (UCL Institute of Child Health, London, UK)
Co-applicants:
Mario Siervo (MRC Human Nutrition Research, UK), Carlos Grijalva-Eternod (UCL, Institute of Global Health, UK), Emma Pomeroy (University of Cambridge, UK)
Title of project:
Understanding variability in cardio-metabolic risk in the ALSPAC cohort
Proposal summary:
Objectives
Primary: 1) To investigate the association between birth order and measures of adiposity (BMI; waist circumference and fat mass, change in fat mass from 9 to 15 years), metabolic (fasting glucose, fasting insulin and lipid profile) and vascular (blood pressure) functions at 15 years old male and female adolescents enrolled in the ALSPAC cohort. 2) A diagnosis of metabolic syndrome will be performed based on measurement of waist circumference, fasting glucose, triglycerides, HDL, blood pressure and the relative risk for metabolic syndrome at age 15 associated with being first-born compared to later-born children will be assessed.
Secondary: We shall test for sex-differences in these associations.
Date proposal received:
Monday, 24 November, 2014
Date proposal approved:
Thursday, 27 November, 2014
Keywords:
Primary keyword:
Cardiovascular