We have discovered that autoantibodies to a C-type lectin MICL promote uncontrolled formation of neutrophil extracellular traps (NETs) that exacerbate autoimmune disease (PMID: 19025564). We have also identified the presence of these autoantibodies in a proportion of our healthy control cohorts and we wish to study this longitudinal cohort to see if the presence of these antibodies early in life predispose to the development of autoimmunity.