B4719 - Multiple population T2DGGI and MAGIC genome-wide association analysis - 18/10/2024

B number: 
B4719
Principal applicant name: 
Laura Corbin | MRC IEU, University of Bristol (UK)
Co-applicants: 
Prof Nic Timpson, Dr Rachel Freathy, Professor Inês Barroso, Dr Camila Armirola-Ricaurte, Annika Jaitner, Dr Aminata Cissé
Title of project: 
Multiple population T2DGGI and MAGIC genome-wide association analysis
Proposal summary: 

MAGIC (the Meta-Analyses of Glucose and Insulin-related traits Consortium) represents a collaborative effort to combine data from multiple cohorts to identify genetic determinants of glycaemic and metabolic traits.

MAGIC investigators study fasting glucose, fasting insulin, 2h glucose and HbA1c, as well as more sophisticated measures of insulin secretion and sensitivity. Through these efforts, dozens of genetic variants influencing these traits have been identified, a subset of which also influence risk of type 2 diabetes.

In this project, we will perform a genome-wide association study of fasting glucose and fasting insulin in G0 mothers and G1 young adults. The results from this analysis will be combined with results from hundreds of other cohorts and contribute to our understanding of the genetic control of these glycaemic traits and how this varies by sex and by genetic ancestry.

Impact of research: 
Identification of new genetic variants associated with glycaemic traits, including information about sex-specific effects.
Date proposal received: 
Thursday, 10 October, 2024
Date proposal approved: 
Friday, 18 October, 2024
Keywords: 
Genetic epidemiology (including association studies and mendelian randomisation), Diabetes, Glycaemic traits and metabolism, GWAS, Biological samples -e.g. blood, cell lines, saliva, etc., Genetics, Genomics, Genome wide association study, Metabolic - metabolism, Sex differences