B4716 - Using placenta transcriptomics to understand molecular mechanisms of pregnancy complications - 18/10/2024
B number:
B4716
Principal applicant name:
Maria Carolina Borges | MRC IEU, University of Bristol (United Kingdom)
Co-applicants:
Jevvy Huang
Title of project:
Using placenta transcriptomics to understand molecular mechanisms of pregnancy complications
Proposal summary:
The Placenta is one of the first organs to develop during pregnancy, beginning to form shortly after the embryo implants in the uterus. The placenta is crucial in providing the fetus with the essential nutrition and oxygen for growth, and when the placenta is not working properly it could cause life threatening conditions to both the baby and the mother. Despite the importance of understanding the structure and functioning of this organ, very little is known about the placenta.
Impact of research:
This project aims to deepen our understanding of placental function and the relationship between the placenta and pregnancy complications. This could help in identifying mechanisms that contribute to pregnancy complications and enhancing current preventive strategies stated by the UK National Institute of Health and Care Excellence (NICE) guidelines. Better knowledge on placenta molecular mechanisms leading to pregnancy complications is needed to inform therapies to prevent and treat such disorders.
Date proposal received:
Monday, 7 October, 2024
Date proposal approved:
Tuesday, 8 October, 2024
Keywords:
Epidemiology, Pregnancy - e.g. reproductive health, postnatal depression, birth outcomes, etc., RNA, Birth outcomes