Although cardiovascular disease (CVD) has traditionally been thought of as a condition that affects older individuals, it is now understood that its origins may begin to develop early in life, during childhood. It is therefore important to identify and promote healthy lifestyle factors in early life stages that may prevent CVD.

Vitamin D has emerged as an important factor in maintaining a healthy cardiovascular system. Low blood levels of vitamin D can lead to inflammation, altered hormone levels, and reduced release of molecules that relax blood vessels. This can in turn raise blood pressure and increase the risk of heart attacks, strokes, and other cardiovascular problems.

Although it is understood that there is an association between vitamin D status and heart health, few studies have explored whether vitamin D concentrations in childhood are related to CVD risk factors and vascular health later in life. To address this gap in the literature, we will use data from the Avon Longitudinal Study of Parents and Children (ALSPAC), which has monitored the health of children from birth into adulthood. Our goal is to determine if higher vitamin D concentrations in the blood during childhood are associated with better vessel function and cardiovascular health indicators – including blood sugar, blood fats, blood pressure, and body fat mass – in adulthood. The goal of this study is to help clarify whether adequate vitamin D concentrations during childhood reduces the risk of developing CVD later in life.