The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that early life, beginning from pregnancy, is a critical exposure window influencing an individual's health and disease risk. This period is especially vital for neurodevelopment, given the significant plasticity of the neural system. Extensive research has demonstrated that gestational complications, parental lifestyle, and environmental exposures during early life can impact the neurodevelopment of offspring, leading to diminished cognitive abilities, increased behavioral and emotional issues, and a higher risk of mental health problems. These exposures might influence early neurodevelopment through complicated genetic-environment interactions. Despite these findings, there remain significant gaps in our understanding of the effects, their underlying mechanisms, and modifiable factors.

This project aims to explore the genetic-environment interactions in the association between early-life exposures and long-term mental health outcomes utilizing data from the ALSPAC cohort. Additionally, we will investigate the potential mechanisms and modifiable factors underlying these associations through a multi-omics approach. This study aims to generate novel insights for early prevention and intervention strategies to enhance childhood and adolescent mental health.