B4669 - Effects of Adverse childhood events on temporary lower appetite - 05/08/2024

B number: 
B4669
Principal applicant name: 
qiyuan zhuang | Huashan Hospital affilated to Fudan University (China)
Co-applicants: 
Yihan Hu
Title of project: 
Effects of Adverse childhood events on temporary lower appetite
Proposal summary: 

Our research aims to uncover the lesser-known effects of childhood physical abuse on temporary changes in appetite and dietary habits. Previous studies in animal models have shown that exposure to physical trauma can lead to a temporary decrease in appetite, a finding that contrasts with the common belief and some human studies suggesting that abuse might lead to an increase in Body Mass Index (BMI) over time. Interestingly, our preliminary studies in older adult cohorts have also indicated a potential long-term increase in baseline BMI in individuals who experienced abuse during childhood. This project seeks to explore these dynamics in a child population using the rich data available from the ALSPAC cohort, focusing on immediate dietary responses and developmental outcomes following episodes of physical abuse.

Impact of research: 
show a neurologic circuit in both human and mice, find out the mechanism behind temporary appetite suppression mechanism
Date proposal received: 
Thursday, 1 August, 2024
Date proposal approved: 
Thursday, 1 August, 2024
Keywords: 
Neurology, Eating disorders - anorexia, bulimia, Statistical methods, BMI