During the COVID-19 pandemic, vaccination efforts were crucial in controlling the spread of SARS-CoV-2. While we know from previous studies that factors including older age, immunosuppression, and obesity contribute to a reduced response to vaccination and increase the risk of breakthrough infection. Host genetic variability is increasingly appreciated to contribute to vaccination variability but contemporary studies lack power and diversity of immune measure and participant inclusion to truly understand the contribution and mechanism of genetic effects. By using statistical genetics approaches this project aims to better understand the role genetics plays in determining response to COVID-19 vaccines in different populations. This analysis may provide valuable insights into the factors influencing vaccine efficacy and inform future vaccine design and deployment strategies worldwide.