The placenta is the crucial interface between mother and developing fetus during pregnancy, enabling exchange of nutrients, oxygen, and waste products. The placenta is essential for a healthy pregnancy; placental pathologies underlie some of the most common pregnancy complications, referred to as placental syndromes (PS). PS include hypertensive disorders of pregnancy (preeclampsia and gestational hypertension), fetal growth restriction, and preterm delivery, which are leading causes of maternal and neonatal mortality and morbidity. PS are associated with adverse cardiovascular health beyond delivery and throughout life, both in the mother and offspring. Yet the placenta remain understudied and the mechanisms linking PS, congenital heart disease in offspring and cardiovascular health in both mothers and offspring are not well understood. In this project we aim to understand the the basis for primary placental disorders as the cause of secondary heart and vascular disease, both in the offspring and in the mother.