Leveraging the genomic and observational data, this study can contribute to revealing the mystery of weight maintenance after weight loss: In most existing obesity interventions, weight loss is always followed by a weight plateau and then weight regain. Only about 15 - 25% of individuals can achieve and maintain a 10% or more significant weight loss with ongoing intervention. In this context, the mystery of weight loss maintenance should be revealed to compare the interactions of weight loss and maintenance.

Therefore, this study aims to explore the genotypes, phenotypes, and environmental correlates of success in weight loss maintenance for children and adolescents by leveraging the genomic and observational data from ALSPAC. According to ALSPAC anthropometry data and the WHO BMI-for-age standards, overweight individuals whose BMI achieves a normal weight range in follow-up years will be enrolled in the analyses. The degree of weight regain will be estimated by the fluctuation of BMI z-scores in follow-up years. This study can be beneficial to interventions aiming at sustaining lost weight, one of the most challenging problems for most individuals with obesity.