Our proposal will exploit longitudinal neuroimaging to evaluate how brain maturation is linked with subclinical psychotic experiences. We have recently developed a method that allows us to identify abnormal maturational trajectories by computing brain centiles (analogous to pediatric growth charts). Applying this methodology to neuroimaging data from individuals with varying levels of psychosis will provide a more complete picture of how this condition progresses in the context of a normative population. Using ALSPAC data from subjects with psychotic experiences will enable us to study how early brain alterations are linked with an initial set of subclinical symptoms and will shed light on how these structural alterations compare to those seen in clinically diagnosed psychotic disorders in the context of a large-scale, multi-study framework.