B4182 - Neurodevelopmental characteristics of children with genetic risk for epilepsy - 31/10/2022
Epilepsy is the most common primary neurological disorder worldwide, with 10% of people experiencing a seizure during their life. Seizures often occur in combination with other neurological or behavioural traits indicating altered brain development. Seizures might also themselves negatively impact the neurocognitive development in early life. Understanding the links between epilepsy and other neurodevelopmental and neurological conditions is key to understanding the mechanism and impact of the disease. Large genome-wide association studies of epilepsy have found specific genes that are linked to brain function and might therefore explain the vulnerability of specific brain circuits in people experiencing seizures. It is not clear though how these genetic predispositions to epilepsy would affect other brain properties, for instance neurocognitive development. Therefore, we propose to investigate the molecular, neurodevelopmental and cognitive outcomes of having a genetic predisposition for epilepsy in the ALSPAC children.