B4173 - From Suicide Ideation to Suicide Attempt Clarifying the Role of Painful and Provocative Events - 24/10/2022
Several leading theories of suicide propose that capability for suicide is acquired across development, in part through exposure to physically painful and/or fear-inducing experiences, collectively referred to as painful and provocative events (PPEs). However, studies investigating the association between exposure to PPEs and risk for suicide attempt are usually cross-sectional (the exposure and outcome are measured at the same time) and do not employ a genetically-informed approach. In this project, we will use data from the ALSPAC study to further characterize the association between PPE exposure and risk for suicide attempt. First, we will test whether the association between genetic liability and risk for suicide attempt is mediated by impulsivity and exposure to PPEs, such as aches and pains, injuries, accidents, and traumatic events. Second, we will investigate whether the magnitude of the association between PPE exposure and risk for suicide attempt in adolescence varies based on parenting behaviors, as positive parenting behaviors may buffer risk associated with exposure to PPEs.