B3856 - Brain development in children at high risk of common mental health disorders - 16/09/2021
The majority of mental health disorders first occur during childhood. The role of brain maturation in the development of mental health disorders is increasingly recognised, and a future aim is to use brain imaging to aid early detection and treatment. In order to gain a holistic view of the development of adolescent mental health, a large dataset incorporating neuroimaging and genetic markers alongside detailed information on environmental exposures is needed. This current proposal would pilot MRI scanning in the Avon Longitudinal Study of Parents and Children Generation 2 study (ALSPAC-G2). We are applying for £100,000 seed funding from the Medical Research Foundation’s Launchpad Grants to pilot this study. We aim to scan a maximum of 50 children twice (subject to costings) and will use this pilot study to determine the logistics for recruiting children at a low and high risk of developing a mental health disorder. Children with a high risk of developing a mental health disorder (50% of the sample) will be selected from parents previously reporting a mental health disorder (according to the CIS-R and self-harm questionnaire). This pilot study will be crucial for assessing whether an adequate sample size of high-risk children can be achieved.