B3877 - Immuno-Metabolic Predictors of Anhedonic Depression and Treatment Response The IMPACT Programme - 16/09/2021
B number:
B3877
Principal applicant name:
Golam Khandaker | University of Bristol - MRC IEU (UK)
Co-applicants:
Title of project:
Immuno-Metabolic Predictors of Anhedonic Depression and Treatment Response: The IMPACT Programme
Proposal summary:
The current work looks to examine the underpinnings of anhedonic depression - i.e. depression associated with an inability to feel pleasure. This is an important group and little is know about the factors that characterise and are important for this outcome. The work will use detailed questionnaires to examine the likely presence or absence of this presentation in ALSPAC participants and there will be extremely detailed followup of a sub-set of participants likely to have this condition. This work will be in parallel with that in a study called NESDA in The Netherlands - providing important replication and sample size.
Impact of research:
Discovery science re. this presentation with likely information re. augmented therapeutic strategies.
Date proposal received:
Sunday, 12 September, 2021
Date proposal approved:
Thursday, 16 September, 2021
Keywords:
Mental health - Psychology, Psychiatry, Cognition, Mental health, Questionnaires, imaging (MRI), biosamples, possible randomised sub study intervention allocation. , Psychiatry, Imaging, Trial, Experimental Medicine