B3827 - Lipid Profile and DNA methylation - from birth for adolescence - 12/07/2021
B number:
B3827
Principal applicant name:
Giulia Mancano | IEU, University of Bristol
Co-applicants:
Dr Gemma Sharp, Dr Janine F. Felix, Giulietta Monasso
Title of project:
Lipid Profile and DNA methylation - from birth for adolescence
Proposal summary:
Unfavourable lipid profile (i.e. dyslipidemia) is an established cause of cardiovascular diseases (CVDs). In recent years, several CpGs sites have been found on lipid-related genes or associated with lipid profiles, supporting the hypothesis that DNA methylation (DNAm) could be involved in regulating these genes and their role in lipid-related diseases [1].
1.Hedman, A.K., et al., Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies. Circ Cardiovasc Genet, 2017. 10(1).
Impact of research:
Build evidence on the link between lipids and DNA methylation and on the mechanistic pathway linking lipids to adverse health outcomes
Date proposal received:
Wednesday, 7 July, 2021
Date proposal approved:
Monday, 12 July, 2021
Keywords:
Epigenetic Epidemiology, Obesity, EWAS, Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Offspring