Gastrointestinal infections are common, with 1 in 4 people in the UK population experiencing an episode each year, which causes an estimated annual cost to the individuals, the National Health Service and the wider economy of £1.5 billion. This research will take a life-course approach to the assessment of the causes and consequences of gastrointestinal infections in the community, from early childhood into early adulthood – continuing into the next generation (ALSPAC-G2 study: Children of the Children of the 90s). This will allow us to provide important insights into changes in causes and consequences of gastrointestinal infections across the individual life-course but also over time at the population level. The findings can then inform public health interventions to reduce the burden of gastrointestinal infections, especially among the most vulnerable groups.