B3447 - Polygenic predictions of blood pressure traits - 17/01/2020
Essential hypertension (HTN) is a leading, preventable risk factor for cardiovascular morbidity and mortality. Recent genome-wide association studies (GWAS) have provided major insight into the genetic architecture of blood pressure (BP) traits, in part due to increasingly large sample sizes. Moreover, novel approaches to genetic risk quantification have been shown to improve upon traditional methods by more accurately incorporating the growing number of genetic markers with observable effects on common complex traits into a single construct, leading to greater predictive power and clinical translation. This project aims to derive and validate risk scores for BP traits and assess their predictive power for HTN and related morbidity and mortality.