B3432 - Hypothesis-free and pQTL analysis of deep vein thrombosis aetiology a Mendelian randomization study - 16/12/2019
B number:
B3432
Principal applicant name:
Emma Vincent | University of Bristol (UK)
Co-applicants:
Andrei-Emil Constantinescu, Caroline Bull
Title of project:
Hypothesis-free and pQTL analysis of deep vein thrombosis aetiology: a Mendelian randomization study
Proposal summary:
Deep vein thrombosis (DVT) usually presents as a blood clot which forms in the deep veins of the legs. It can be a life-threatening disease if not identified in time, leading to pulmonary embolism or heart failure. While research have found some risk factors using observational epidemiological studies, little is known about the exact causes of DVT.
Impact of research:
The likely output of this research will be a publication, contributing to the field of deep vein thrombosis research (DVT). We hope to strengthen evidence for suggested risk factors and to identify novel ones. We hope our study would therefore lead to the advancement of the knowledge of the field and might influence future clinical applications for DVT.
Date proposal received:
Friday, 13 December, 2019
Date proposal approved:
Monday, 16 December, 2019
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation), Obesity, Deep vein thrombosis, Statistical methods, Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., BMI, Cardiovascular, Genetic epidemiology, Mendelian randomisation