B3429 - Obesity and Inflammation - 16/12/2019

B number: 
B3429
Principal applicant name: 
Komal Satti | Dartmouth-Hitchcock medical center, New Hampshire USA (United States of America)
Co-applicants: 
Title of project: 
Obesity and Inflammation
Proposal summary: 

Between 2015 and 2016, obesity affected approximately 13.7 million children and adolescents in the United States. Children with obesity are more likely to have high blood pressure, abnormal lipids and insulin resistance even though overt cardiovascular disease may not develop for decades.Additionally, children with obesity are at increased risk for musculoskeletal and mental health disorders, as well as certain cancers. This project aims to to better understand the development and progression of the metabolic derangement seen with obesity in children as well as the associations with development of comorbidities. Inflammation is considered to be the common link between obesity and its progression to various comorbidities. If we are able to identify an early signal in children with obesity who are more likely to develop diseases such as asthma, cardiovascular disease and cancers we will be able to address the problem in a timely fashion and offer focused intervention and treatment to these high risk children

Impact of research: 
The findings from the proposed study will help lay a solid foundation for future proposed work in the use of metabolic markers to identify and prevent childhood obesity-related diseases. At the successful completion of this project we expect to have gained useful insights into the underlying mechanisms and trends of obesity leading to its end outcomes.
Date proposal received: 
Tuesday, 10 December, 2019
Date proposal approved: 
Monday, 16 December, 2019
Keywords: 
Clinical research/clinical practice, Obesity, Statistical methods, Biological samples -e.g. blood, cell lines, saliva, etc., Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., BMI, Breast feeding, Cardiovascular, Growth, Nutrition - breast feeding, diet, Physical - activity, fitness, function