B3374 - Is the polygenic risk score for Alzheimers disease and cognitive function manifest in childhood/adolescent brain structures - 16/09/2019
B number:
B3374
Principal applicant name:
Neil Davies | Integrative Epidemiology Unit (United Kingdom)
Co-applicants:
Roxanna Korologou-Linden, Emma Anderson, Yoav Ben-Shlomo, Laura Howe
Title of project:
Is the polygenic risk score for Alzheimer’s disease and cognitive function manifest in childhood/adolescent brain structures?
Proposal summary:
This project will try to understand how early Alzheimer's disease is manifest through the use of genetic risk scores. Genetic risk scores (irrespective of whether an individual has Alzheimer's disease) are useful in examining prodromal phenotypes. We aim to investigate whether Alzheimer's disease is manifest in childhood and adolescence through the use of brain MRI data in ALSPAC.
Impact of research:
To understand how early Alzheimer's disease in manifest.
Date proposal received:
Friday, 13 September, 2019
Date proposal approved:
Monday, 16 September, 2019
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation), Mental health, Statistical methods, Mendelian randomisation