B3319 - Clinical and cognitive profiles of adults with psychotic experiences with and without preceding PTSD - 28/05/2019

B number: 
B3319
Principal applicant name: 
Tjasa Velikonja | Icahn School of Medicine at Mount Sinai (USA)
Co-applicants: 
Eva Velthorst
Title of project: 
Clinical and cognitive profiles of adults with psychotic experiences, with and without preceding PTSD
Proposal summary: 

There is substantial evidence demonstrating that in addition to the well-established link between exposure to childhood trauma and Posttraumatic Stress Disorder, PTSD has been associated with an increased risk for other severe psychiatric disorders such as psychosis. Individuals with psychosis have been found to have higher comorbid rates of PSTD compared to the general population (30%-50% vs 7%-9%). Importantly, the link between psychosis and PTSD is complex and multifactorial. There is very little knowledge on what could explain the high comorbidity between PTSD and psychosis, and more specifically the mechanisms/pathways that may explain why trauma may lead to psychotic symptoms, PTSD or to a combination of both. To date, the literature has focused on two main hypotheses: a) PTSD stands as a mediator of the relationship between childhood trauma and psychotic symptom severity. A model of continuity has also been suggested, implying that psychotic symptoms would be an exacerbation of the PTSD symptoms and b) PTSD and psychosis are both part of a broader spectrum of reactions to trauma with similar explanatory mechanisms at the level of cognitive schemas (e.g. beliefs about self and others), attributional styles and dissociative processes. There is a paucity of empirical evidence evaluating either of these hypotheses. Examining clinical and cognitive profiles of adults with psychotic experiences, with and without preceding PTSD (after childhood trauma) would be the first step towards disentangling complex relationship between the two disorders.

Impact of research: 
The course of the illness, prognosis and treatment for psychosis (i.e. schizophrenia) and PTSD are very different, therefore, advancing knowledge on this complex relationship between psychosis and PTSD after childhood trauma is crucial in guiding targeted clinical interventions.
Date proposal received: 
Friday, 24 May, 2019
Date proposal approved: 
Tuesday, 28 May, 2019
Keywords: 
Mental health - Psychology, Psychiatry, Cognition, Mental health, PTSD, psychosis, cognition