B3250 - PACE maternal mid-pregnancy Vitamin D and offspring cord blood methylation - 07/02/2019
B number:
B3250
Principal applicant name:
Matthew Suderman | IEU (United Kingdom)
Co-applicants:
Elizabeth Diemer
Title of project:
PACE maternal mid-pregnancy Vitamin D and offspring cord blood methylation
Proposal summary:
Low maternal vitamin D during pregnancy has been associated with a wide range of health outcomes in offspring, including bone health, symptoms of Attention Deficit-Hyperactivity Disorder, symptoms of Autism Spectrum Disorder, and autoimmune conditions. Methylation is one mechanism by which maternal vitamin D in the prenatal period might impact offspring health. We propose to test associations between maternal mid-pregnancy Vitamin D and offspring cord blood methylation. To maximise power, we will meta-analyze associations in multiple cohort studies including ALSPAC within the Pregnancy and Childhood Epigenetics consortium (https://www.niehs.nih.gov/research/atniehs/labs/epi/pi/genetics/pace/ind...).
Impact of research:
A final answer about whether or not maternal serum vitamin D levels during pregnancy affects cord blood methylation. If the answer is positive, then we will be closer to understanding how maternal vitamin D levels affect offspring.
Date proposal received:
Tuesday, 5 February, 2019
Date proposal approved:
Thursday, 7 February, 2019
Keywords:
Epigenetic epidemiology, Pregnancy - e.g. reproductive health, postnatal depression, birth outcomes, etc., Microarrays, Biological samples -e.g. blood, cell lines, saliva, etc., Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Epigenetics, Nutrition - breast feeding, diet