B3238 - Early-life nutritional programming of metabolic health through epigenetic pathways - 15/01/2019
B number:
B3238
Principal applicant name:
Gemma Sharp | University of Bristol (United Kingdom)
Co-applicants:
Dr Laura Johnson
Title of project:
Early-life nutritional programming of metabolic health through epigenetic pathways
Proposal summary:
Pregnancy and infancy are critical periods for nutritional programming of metabolic health. Epigenetic changes seem to have a crucial role in pathways leading from early-life nutrition to metabolic health across the life course. The NUTRIprogram consortium (University of Bristol, Erasmus University Rotterdam, IS-Global Barcelona, University of British Columbia and LMU) has been set up to facilitate research in this area. We will study key maternal and infant nutrition-related exposures in relation to DNA methylation in mothers and offspring at different ages, and metabolic health across the life course.
Impact of research:
NutriPROGRAM will develop a sustainable, translational, international collaboration for studies on nutrition and epigenetics and their role in sustaining good health throughout the life course.
Date proposal received:
Thursday, 10 January, 2019
Date proposal approved:
Tuesday, 15 January, 2019
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation), Pregnancy - e.g. reproductive health, postnatal depression, birth outcomes, etc., Nutrition/diet, Metabolomics, Statistical methods, Biological samples -e.g. blood, cell lines, saliva, etc., Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Mothers - maternal age, menopause, obstetrics, Offspring, Physical - activity, fitness, function, Birth outcomes, Blood pressure, Childhood - childcare, childhood adversity, Development, Epigenetics, Fathers, Genetic epidemiology, Mendelian randomisation