We would like to access the Children of the 90s and their parents’ genetic data and some imaging and blood biomarker information in order to characterise “favourable adiposity” genes. By this we mean versions of genes (alleles) that result in a higher BMI and body fat but lower risk of diseases such as type 2 diabetes, hypertension and heart disease. Current studies have already identified 14 alleles associated with higher body fat % but lower risk of these diseases. We know that some of these “favourable adiposity” genes operate by putting more fat in the lower body, resulting in a lower waist to hip ratio (“pear” rather than “apple” shape) in women. Using MRI imaging from adults, we know that these alleles add more fat under the skin (subcutaneous) but less fat to the liver. These genes have been discovered in adults, and we would now like to test what they are doing in childhood and adolescents in the CO90s. To do this, we’d like to link the gene variants we are finding in adults to body fat imaging and circulating blood markers at all time points in childhood and adolescence where available. We’d like to analyse the parent’s data to help in the discovery of these genetic variants by analysing with other large studies of adults.