B3224 - DNA Methylation in Spastic Type Cerebral Palsy - 13/12/2018
B number:
B3224
Principal applicant name:
Robert Akins | Nemours - Alfred I. duPont Hospital for Children (USA)
Co-applicants:
Title of project:
DNA Methylation in Spastic Type Cerebral Palsy
Proposal summary:
We are interested in differences in DNA methylation patterns among children with medical conditions acquired before or shortly after they were born. These conditions have no known genetic cause, and we think epigenetic phenomena -- like DNA methylation -- may account for some of their symptoms. We already have information about DNA methylation differences; we would like to evaluate our data using information from ALSPAC about how stable DNA methylation might be over time at different sites.
Impact of research:
We believe that a discriminating signal will be identified in our existing cohorts. If true, the results will be published, and the data will be used as justification for future grant submissions.
Date proposal received:
Wednesday, 5 December, 2018
Date proposal approved:
Thursday, 6 December, 2018
Keywords:
Molecular genetics and genomics, Developmental disorders - autism, Congenital abnormalities, Pregnancy - e.g. reproductive health, postnatal depression, birth outcomes, etc., Computer simulations/modelling/algorithms, Statistical methods, Spastic type cerebral palsy; static encephalopathy; physical disability.