B3223 - Resemblance of parent-offspring dietary patterns and the development of offspring cardio-metabolic risks - 06/12/2018

B number: 
B3223
Principal applicant name: 
Abdullah Al Mamun | The University of Queensland (Australia)
Co-applicants: 
Professor Harold David McIntyre, Sonia Pervin
Title of project: 
Resemblance of parent-offspring dietary patterns and the development of offspring cardio-metabolic risks
Proposal summary: 

Parents are believed to strongly influence the health behaviours of their offspring. It is also believed that parents are gatekeepers and function as important role model for the development of offspring health behaviours such as diet, physical activity, sedentary behaviour and sleeping. Diets has been considered as one of most important health behaviours that offspring adapt from parents throughout development stages of life including early childhood and adolescent period. In the life course epidemiology, diets has been considered as one of most important modifiable risk factors for the development of cardio-metabolic diseases. Most previous studies on the resemblance of parent-offspring dietary patterns were based on small sample and cross-sectional design. There is no study that considered (1) parent-offspring resemblance from early life to adulthood using repeated measures of parent-offspring diets; (2) whether this resemblance was influenced by other life style factors such as physical activity, sedentary behaviours, and sleeping (3) pathways of the resemblance of dietary trajectories predict the progression of offspring cardio-metabolic risks. Finally, (4) whether the genetic predisposition factors in parent-offspring dietary resemblance also contribute to the development of cardio-metabolic risk.

To our knowledge, this will be the first study to evaluate the parent-offspring dietary resemblance through a longitudinal cohort considering a range of other behavioural factors and genetic predisposition to the progression of cardio-metabolic risk factors throughout the life course. The Knowledge from this study will help to design effective family based early life intervention; identify appropriate target group, and period of intervention for healthy dietary habit as a prevention of later life chronic diseases.

Impact of research: 
The knowledge to be generated from this study will inform the health policymaker and practitioner- how parent-offspring dietary resemblance over the life course plays key role in the development of diseases. The contribution of different factors shared by family members (eg; genetics, and lifestyle behaviours). This knowledge will also help to know pathways for diet-disease relationship. Thus, this study will inform us whether individual or family should be targeted for early life prevention intervention to avoid later life cardio-metabolic diseases.
Date proposal received: 
Wednesday, 5 December, 2018
Date proposal approved: 
Thursday, 6 December, 2018
Keywords: 
Epidemiology, Cardio-metabolic diseases eg; cardiovascular diseases, behaviour-risk behaviour, Diabetes, Hypertension, obesity, Statistical methods,GWAS, polygenic score, Cardio-metabolic disease, Nutrition- Breastfeeding, diet;BMI, Blood Pressure, Physical activity, Sleep, Genetics