B3187 - Co-development of sensory activity and mental health symptoms - 25/09/2018

B number: 
B3187
Principal applicant name: 
Teresa Tavassoli | University of Reading (United Kingdom)
Co-applicants: 
Keren MacLennen
Title of project: 
Co-development of sensory activity and mental health symptoms
Proposal summary: 

We all perceive the sensory world around us differently. Some autistic children for example are overwhelmed by sounds or touch. This can make everyday situations such as visiting a busy supermarket a challenging task for families. Being overly sensitive has also been linked to anxiety. This project will explore if sensory reactivity, such as being oversensitive to sounds, can predict later anxiety and related mental health symptoms. To do so we would analyse already collected ALSPAC data on sensory reactivity and mental health symptoms from 6 months of age onwards. This includes already collected caregivers questionnaires about how their child reacts to the sensory world around them, such as sounds and lights, and questions about anxiety. That way we can test if the relationship between sensory reactivity and anxiety and related mental health issues is stable over time. Also we can test if early sensory reactivity can predict later mental health symptoms. Identifying whether sensory reactivity predicts mental health symptoms over time could lead to a clinical impact. If sensory reactivity symptoms such as being oversensitive to sounds are identified and treated earlier, it might be possible to reduce the impact of subsequent mental health problems, such as anxiety. Last, this project will allow us to investigate genetic underpinnings of sensory reactivity and identify potential biomarkers for sensory reactivity issues, such as hyper-and-hypo reactivity.

Impact of research: 
Anxiety and related mental health symptoms is at the core of this project. Anxiety ranks very high amongst the factors that influence mental health and quality of life, and is therefore one of the key dependent variables of this project. The proposed research will investigate the role of sensory reactivity in the co-evolution of mental health symptoms, focusing particularly on anxiety. If evidence in support of a causal role for sensory reactivity is found by the project, it can potentially lead to long-term clinical impact. Early identification of sensory reactivity symptoms such as hyperreactivity can in turn be used to make modifications to lifestyle and environment, thereby reducing the probability of development of anxiety. Moreover, if sensory reactivity symptoms such as hyperreactivity are identified and treated earlier, it might be possible to reduce the impact of subsequent mental health problems, such as anxiety. Elucidating the critical co-evolution of sensory reactivity, anxiety and related mental health symptoms , can lead to clinical impact by identifying sensitive time points for intervention and to the development of personalizing treatments according to sensory subtype and related mental health outcome.
Date proposal received: 
Tuesday, 25 September, 2018
Date proposal approved: 
Tuesday, 25 September, 2018
Keywords: 
Mental health - Psychology, Psychiatry, Cognition, Developmental disorders - autism, Statistical methods, Development