B3161 - Childhood BMI trajectories and DNA methylation in adolescents from Birth to Twenty and ALSPAC - 31/08/2018
B number:
B3161
Principal applicant name:
Gemma Sharp | IEU (United Kingdom)
Co-applicants:
Title of project:
Childhood BMI trajectories and DNA methylation in adolescents from Birth to Twenty and ALSPAC
Proposal summary:
Two recent large studies of adults found over 200 positions on the genome where variation in blood DNA methylation was associated with body mass index (BMI). At the majority of these sites, the direction of estimated effect seems to be from BMI to methylation, rather than vice versa. It is still unclear how long individuals need to be "exposed" to higher BMI before the associated changes in DNA methylation are seen, and how changes in BMI over the lifecourse might be associated with DNA methylation.
Impact of research:
This study will help show whether effects of BMI on methylation are apparent at adolescence.
Date proposal received:
Tuesday, 14 August, 2018
Date proposal approved:
Wednesday, 15 August, 2018
Keywords:
Epidemiology, Obesity, DNA sequencing, Biological samples -e.g. blood, cell lines, saliva, etc., BMI, Childhood - childcare, childhood adversity, Epigenetics