B3172 - Multi-modal Phenotype Platform for Next-Generation Health Data Science - 30/08/2018

B number: 
B3172
Principal applicant name: 
Vasa Curcin | Kings College London
Co-applicants: 
Emily Jefferson, Andy Boyd
Title of project: 
Multi-modal Phenotype Platform for Next-Generation Health Data Science
Proposal summary: 

"Inconsistent representation of the clinical context is among the biggest barriers to broad-scale adoption of precision medicine [and] a consistent approach to the digital representation of clinical features is urgently required.” (Charles Gutteridge, CCIO Barts Hospital, London). The interpretation of health data records (and other complex data) is complicated, with inconsistent recording, interpretation and selection. This may mean that error and bias enters research studies using health records or that error and bias enters the way in which research findings are interpreted. This project aims to conduct methodological work to alleviate the risks of these issues and to increase the possibilities harmonised and repeatable research across different data resources. ALSPAC data can help inform these investigations given its range of complex data collected directly from individuals, from linked records and potentially from 'digital footprint' sources (such as sensors/social media).

Impact of research: 
Impacts 1) Act as a cornerstone of HDR UK Information Commons infrastructure. 2) Support for researchers in creation of new phenotypes and sharing them with the community. 3) Create efficiencies for health care organizations that must increasingly support growing numbers of data requests related to comparative effectiveness research (CER), quality improvement, and chronic disease management. 4) Accelerate impact of discovery through increased transparency and replicability 5) Maximise the usability and value of existing data repositories and opening them to new users through directly usable phenotypes. 6) Establish standards and best practices for UK health data providers, including EHR companies.
Date proposal received: 
Wednesday, 29 August, 2018
Date proposal approved: 
Wednesday, 29 August, 2018
Keywords: 
Health Services Research/Health Systems Research, Data Linkage