B3143 - Molecular trajectories of healthy childhood development Swath Proteomics - 01/08/2018
B number:
B3143
Principal applicant name:
Nic Timpson | University of Bristol
Co-applicants:
Prof Andrew Dowsey , Dr Susan Ring, Prof John MacLeod, Prof Tony Whetton, Prof Simon Hubbard, Dr Nophar Geifman, Dr Adam Stevens
Title of project:
Molecular trajectories of healthy childhood development (Swath Proteomics)
Proposal summary:
We will measure levels of thousands of proteins and peptides present in biological samples collected from ALSPAC participants at 3 or more ages using a novel methodolgy (SWATH Mass spectrometry). This will enable us to identify biomarkers which change as individuals develop and biomarkers that show differences between individuals. This data will be analysed in association with the comprehensive data available from ALSPAC participants, including genetic, phenotypic, environmental exposure and outcome data to look for reasons for differences. This analysis could identify biomarkers associated with particular outcomes and how these change during development or why different individuals have different outcomes.
Impact of research:
Discovery of biomarkers related to development. A by product of the research will be a protomics data resource for the scientific community.
Date proposal received:
Monday, 2 July, 2018
Date proposal approved:
Tuesday, 3 July, 2018
Keywords:
Bioinformatics, Proteomics, Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc.