B3152 - Vitamin B12 intake in pregnancy and offspring outcomes - 24/07/2018
B number:
B3152
Principal applicant name:
Jean Golding | UoB
Co-applicants:
Dr Joseph Hibbeln, Yasmin Iles-Caven
Title of project:
Vitamin B12 intake in pregnancy and offspring outcomes
Proposal summary:
Vitamin B12 deficiency is reported to have a deleterious effect on the brain, particularly in regard to mood and behaviour. There is a lack of evidence concerning whether maternal prenatal deficiency has an adverse effect on the child.
This proposal is to assess whether there are any long-term adverse effects on the child's behaviour, mood and development. This will use the classification of the components of the mothers' diets at 32 weeks gestation, as well as the genetic variants associated with vitamin b12 metabolism to carry out the neurocognitive phenome scan as developed by the Golding group.
Impact of research:
Depending on what we find - we should be able to recommend whether supplements are needed in certain subgroups (e.g. vegans or vegetarians).
Date proposal received:
Monday, 23 July, 2018
Date proposal approved:
Tuesday, 24 July, 2018
Keywords:
Epidemiology, Addiction - e.g. alcohol, illicit drugs, smoking, gambling, etc., Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Cognitive impairment, Eating disorders - anorexia, bulimia, Epilepsy, Learning difficulty, Mental health, Speech/language problem, Statistical methods, Childhood - childcare, childhood adversity, Cognition - cognitive function, Speech and language, Communication (including non-verbal), Development, ENT - hearing, Environment - enviromental exposure, pollution, Handedness, Intelligence - memory, Methods - e.g. cross cohort analysis, data mining, mendelian randomisation, etc., Psychology - personality