Nearly 40% of children worldwide experience adversities, including physical and sexual abuse, parental death, and poverty. Childhood adversities tend to be reproduced across generations, resulting in entrenched cycles of mental disorders and disadvantage. Epigenetic markers could also signal these transgenerational programming effects and may be important for understanding the biological aspects of mental health risk transmission and for informing intervention targets/measures. This study aims to conduct a genome-wide analysis to identify a DNA methylation signature associated with intergenerational transmission of mother’s childhood adversity.