B3144 - Genome-wide association study of dietary intake as part of the Social Sciences Genetic Association Consortium - 04/07/2018
B number:
B3144
Principal applicant name:
Kaitlin Wade | MRC Integrative Epidemiology Unit (United Kingdom)
Co-applicants:
Title of project:
Genome-wide association study of dietary intake as part of the Social Sciences Genetic Association Consortium
Proposal summary:
Understanding the effects of nutrition on health is a priority given the obesity epidemic in Western countries. We aimed to identify genetic changes related to dietary intake in a large-scale collaboration including multiple cohorts and consortia across the world including the Avon Longitudinal Study of Parents and Children (ALSPAC) in the United Kingdom.
Impact of research:
Future research, which may utilize genetic variants associated with diet composition as instrumental variables, may be used to establish magnitude and direction of causation between dietary intake and health outcomes. Our GWAS summary statistics may be used to study such environmental effects in more depth, for instance in the context of gene-environment interaction studies. In addition, our results could be used to assess the “evolutionary mismatch” between our current environment, and dietary environments of the pre-agricultural revolution.
Date proposal received:
Tuesday, 3 July, 2018
Date proposal approved:
Wednesday, 4 July, 2018
Keywords:
Genetics, Behaviour - e.g. antisocial behaviour, risk behaviour, etc., GWAS, Genetics, Genome wide association study, Mothers - maternal age, menopause, obstetrics, Nutrition - breast feeding, diet