B3058 - Neurocognitive effects of prenatal psychotropic medication exposure throughout development - 13/03/2018

B number: 
B3058
Principal applicant name: 
Jeffrey Gruen | Yale University (USA)
Co-applicants: 
Dr. Amanda Rendall, Dr. Chintan Mehta
Title of project: 
Neurocognitive effects of prenatal psychotropic medication exposure throughout development
Proposal summary: 

The goal of this project is to evaluate how maternal use of antidepressants and/or anxiolytic medication during pregnancy may have long-lasting consequences on a child’s neurocognitive development. The overall use of prescription medication (particularly antidepressants) by pregnant women has increased steadily over the past three decades. These medications are able to pass the placental barrier and are secreted in breast milk, which raises concerns about adverse effects on a child’s neurodevelopment. Additionally, maternal mood directly influences fetal and infant development through biological, genetic and indirect environmental mechanisms. Therefore, the benefits and risks of receiving pharmacological treatment during pregnancy must be assessed on an individual basis. Recent studies have demonstrated an increase risk in neurodevelopmental disorders such as autism spectrum disorders (ASD) and attention-deficit hyperactivity disorder (ADHD) when exposed to antidepressants prenatally. However, very little research has explored possible effects of prenatal exposure on the developmental trajectory of cognitive skills and language/communication abilities. To date, no studies have explored possible interactions between medication exposure and genetic factors in these cases.

Impact of research: 
The goal of this research is to assess the benefits and consequences of taking psychotropic medication during pregnancy. These assessments should be taken on an individual basis, any incremental risk must be weighed against serious consequences of failing to treat depression/anxiety and related disorders. However, in some cases alternative treatment to pharmacological intervention may be warranted and beneficial. Evaluating genetic risks may assist balancing the benefits and risks of prenatal exposure to psychotropic medications. Results from the research will likely appear in peer-reviewed journals and be presented at conferences.
Date proposal received: 
Wednesday, 31 January, 2018
Date proposal approved: 
Thursday, 1 February, 2018
Keywords: 
Genetics, Developmental disorders - autism, Cognitive impairment, Learning difficulty, Mental health, Pregnancy - e.g. reproductive health, postnatal depression, birth outcomes, etc., Speech/language problem, GWAS, Qualitative study, Statistical methods, Cognition - cognitive function, Communication (including non-verbal), Development, Genetics, Genome wide association study, Speech and language, Statistical methods