B2476 - Genetics of common childhood infectious diseases - 02/07/2015
B number:
B2476
Principal applicant name:
George Mc Mahon | University of Bristol
Co-applicants:
Title of project:
Genetics of common childhood infectious diseases
Proposal summary:
Genetic variation at the FUT2 locus on chromosome 19 (secretor/non secretor) predisposes to at least two infectious diseases. Being a secretor leads to genetic immunity to gastroenteritis in adults caused by infection by the Norwalk norovirus and fucosylated oligosaccharides in the breastmilk of secretors are protective against gastroenteritis children. Using genotype data I will examine whether protective effects of maternal secrector status are present for breastfed children.
Date proposal received:
Tuesday, 30 June, 2015
Date proposal approved:
Thursday, 2 July, 2015
Keywords:
Genetics, Infection, GWAS, Statistical methods, Immunity