2490 - Maternal Epigenetic Predictors of Height BMI and Heritability Variance
Complex genetic traits are traits (e.g height and BMI) are multifactorial and can’t explained by variation in single genes.. To understand the genetic basis of such traits, investigators have queried across the genome to find multiple variants associated with the traits, such as the genome-wide association study (GWAS). Another possibility is to look at modifications to DNA itself that may change how genes behave - these changes are epigenetic (epi, meaning on or upon). We propose to explore how maternal epigenetic modifications are associated to their children’s height and BMI. In addition, we will try to understand how epigenetic modifications can play a role in determining how similar the heights and BMIs of a mother and her child will be.