ALSPAC has generated many cell lines from white blood cells. We would like to exploit this resource by treating some of the cell lines in a specific way to produce induced pluripotent stem cells (also known as iPS cells or iPSCs). iPS cells can be programmed to take up characteristics of different cell types, for example cardiac or skin cells. Producing such cells from the ALSPAC participants will enable researchers to look the effects of different genetic variants or environmental exposures on different types of cells helping to determine the mechanisms of disease. The aim of this project is to establish procedures and processes for creation and use of iPS cells from the ALSPAC cohort to enhance future research.