B2502 - The role of the chemical exposome in determining the aetiology of urogenital malformations in the male neonate
B number:
B2502
Principal applicant name:
Elizabeth Hill | University of Sussex, UK (United Kingdom)
Co-applicants:
Dr Kasia Kordas, Dr Tim Ebbels
Title of project:
The role of the chemical exposome in determining the aetiology of urogenital malformations in the male neonate.
Proposal summary:
Urogenital malformations in male neonates is thought to be associated with exposure of the foetus to mixtures of endocrine disrupting chemicals during pregnancy. However, the causative chemical agents and their mixtures have not yet been identified. This project will use new discovery-based chemical methods to analyse samples of maternal urine from an ALSPAC cohort containing cases with urogenital malformations. The goal of the work is to identify key mixtures of chemical contaminants that have endocrine disrupting activity and cause malformations in the developing foetus.
Date proposal received:
Tuesday, 21 July, 2015
Date proposal approved:
Wednesday, 12 August, 2015
Keywords:
Toxicology, Pregnancy - e.g. reproductive health, postnatal depression, birth outcomes, etc., cryptorchidism
hypospadias, Mass spectrometry, Metabolomics, Biological samples -e.g. blood, cell lines, saliva, etc., Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Birth outcomes, Cohort studies - attrition, bias, participant engagement, ethics, Endocrine - endocrine disrupters, Environment - enviromental exposure, pollution, Metabolic - metabolism