B2513 - Sex specific association of asthma with DMRT1 variants - 21/08/2015
B number:
B2513
Principal applicant name:
John Henderson | ALSPAC
Co-applicants:
Dr. Maximilian Schieck, Prof. Michael Kabesch, Prof Marieke Boezen
Title of project:
Sex specific association of asthma with DMRT1 variants.
Proposal summary:
A gene (DMRT1) was found to be associated with asthma in a Dutch study. This failed to replicate in ALSPAC; the effects were in the opposite direction to those found in the discovery cohorts and other replication samples. We are investigating the reasons for this by doing some further analyses of the genetic variants in his region.
Date proposal received:
Tuesday, 18 August, 2015
Date proposal approved:
Friday, 21 August, 2015
Keywords:
Genetics, Allergy, Respiratory - asthma, GWAS, Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc., Sex differences