B2530 - statistical method development and application for genetic fine mapping using meta-analysis summary statistics - 18/09/2015

B number: 
B2530
Principal applicant name: 
Jie Zheng | MRC IEU (UK)
Co-applicants: 
Dr. Tom Gaunt, Dr. Santiago Rodriguez , Prof Dave Evans
Title of project: 
statistical method development and application for genetic fine mapping using meta-analysis summary statistics
Proposal summary: 

This project is aiming to develop a genetic fine mapping tool (HAPRAP) using meta-analysis summary statistics only. The method can be used as a model selection approach for 2 sample MR.
We are also aiming to apply HAPRAP to all public available GWAS meta-analysis summary statistics.

Date proposal received: 
Thursday, 10 September, 2015
Date proposal approved: 
Friday, 18 September, 2015
Keywords: 
Genetics, GWAS, Statistical methods, Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc., Statistical methods