Optimism is a complex behavioural trait estimated to be around 40% heritable. This is supposed to be the result of many genes of small effects, as well as complex environmental interactions. This study uses the method of genome-wide association studies (GWAS) to search for single nucleotide polymorphisms (SNPs - specific common variation found in DNA) which relates to levels of optimism and hopefulness. A GWAS of optimism in a sample of twins (TEDS) found two genetic markers known as single nucleotide polymorphisms (SNPS) to be associated.

The next stage of this research is to see if these significant SNPs are replicable in the ALSPAC sample. The overall aim of the research is to be able to better understand what characterises positive psychological aspects of wellbeing and use this information to better inform wellbeing interventions.