B2540 - Dopamine related polymorphisms in healthy memory and dementia

B number: 
B2540
Principal applicant name: 
John Grogan | University of Bristol (Bristol)
Co-applicants: 
Dr Tom Gaunt
Title of project: 
Dopamine related polymorphisms in healthy memory and dementia
Proposal summary: 

Dopamine is a chemical in the brain involved in reward, pleasure, addiction, and memory. Recent evidence has linked it to memory performance, and even affecting memory decline in dementia patients. We will look to see if genetic differences that affect dopamine activity affect memory performance over time (i.e. does having higher levels of dopamine slow memory decline over age) and dementia progression.

Date proposal received: 
Monday, 21 September, 2015
Date proposal approved: 
Friday, 2 October, 2015
Keywords: 
Epidemiology, Computer simulations/modelling/algorithms, Statistical methods, Linear regressions will be used to determine association between outcomes and exposures, adjusting for "confounders" where appropriate., Ageing, Cognition - cognitive function, Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc., Neurology