B2567 - Multiple risk behaviours and DNA methylation in children and adolescents - 05/11/2015
B number:
B2567
Principal applicant name:
Frank | SSCM University of Bristol (UK)
Co-applicants:
Rona Campbell, Jon Heron, Matt Hickman, Kate Tilling, Caroline Relton, Matt Suderman, Laura Howe
Title of project:
Multiple risk behaviours and DNA methylation in children and adolescents
Proposal summary:
The aim of this study is to investigate whether there are epigenetic markers from birth to age 17 years which are related to multiple risk behaviour at age 7 and 17 years in a dose-dependent manner. Previous research on multiple risk behehaviours has been conducted in ALSPAC by some of this proposal's applicants, and the results of those analyses will enable linkage to ARIES DNA methylation data. Participants have been classified in multiple risk behaviour 'risk classes' at age 17/18, and associations will be explored with epigenetic signals at birth, age 7 and age 17 using univariate, multivariate, and Bayesian mixture statistical modelling methods. Multivariate statistical models will be adjusted for potential confounding factors.
Date proposal received:
Wednesday, 4 November, 2015
Date proposal approved:
Thursday, 5 November, 2015
Keywords:
Epidemiology, Addiction - e.g. alcohol, illicit drugs, smoking, gambling, etc., Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Mental health, Epigenetics, Cohort studies - attrition, bias, participant engagement, ethics, Childhood - childcare, childhood adversity, Genetics - e.g. epigenetics, mendelian randomisation, UK10K, sequencing, etc., Social science, Statistical methods, multiple risk behaviour