B2568 - Genome-wide analysis of early skeletal growth using 1000 Genomes imputed data - EGG consortium
Common genetic variants have been identified for length and head circumference in children and adults. In a previous genome-wide association (GWA) study two single nucleotide polymorphisms (SNPs) were found to be associated with head circumference in childhood. Additionally, 1 SNP was found to be associated with length in early life. However, these studies used datasets imputed to the Hapmap reference panel, consisting of 2.5 million SNPs. Since then, a more detailed reference panel has become available, the 1000 genomes reference panel, which offers the opportunity to identify more and better imputed SNPs. In addition, the number of studies with GWAs data has increased. Therefore, we will be able to analyze more samples, giving us a larger power to detect associations.